数据科学家

北京热心肠生物技术研究院有限公司

北京, 中国

2020 - 2019-11-3

Post-doc Lecturer

College of Resources and Environment

Huazhong Agricultural University

2019-10-1 - 2016-3-2

Post-doctoral Fellow

School of Life Science

University of Science and Technology of China

2015 - 2013

Lecturer

School of Food and Biological Engineering

Hubei University of Technology

2012

PhD., Microbiology

Huazhong Agricultural University

Wuhan, CN

2012 - 2007

• Thesis: The characterization of a novel ArsR-type regulator in Mycobacterium tuberculosis and the characterization of molecular basis of isoniazid drug resistance in Mycobacteria

B. S., Biotechnology

Huazhong Agricultural University

Wuhan, CN

2008 - 2004

• bachelor-master continous program

The SCELSE Summer Course

Singapore Centre for Environmental Life Sciences Engineering

Singapore, SG

2016

土壤微生物新理论新技术研讨会暨培训班

中科院南京土壤所

Nanjing, CN

2018-11-17 - 2018-11-15

““不忘初心，牢记使命”教工党员培训班"

韶山干部培训学院

Shaoshan, CN

2018

Whole genome protein-protein and TF-promoter interactome in M. tuberculosis

College of Life Science and Technology

Huazhong Agricultural University

2007 - 2009

We used a bacterial two-hybrid method to construct the whole genome protein-protein interaction (PPI) network, and a bacterial one-hybrid method to construct the whole genome transcriptional regulator (TF) - promoter interaction network in M. tuberculosis.

Novel transcriptional regulator in mycobacteria

College of Life Science and Technology

Huazhong Agricultural University

2009 - 2012

• An ArsR-like transcriptional factor recognizes a conserved sequence motif and positively regulates the expression of phoP in mycobacteria
• A TetR-like regulator broadly affects the expressions of diverse genes in Mycobacterium smegmatis
• Characterization of a Novel ArsR-Like Regulator Encoded by Rv2034 in Mycobacterium tuberculosis

The intra-action between three RelBE modules and inter-action between RelBE3/SirR

College of Life Science and Technology

Huazhong Agricultural University

2009 - 2014

• Characterization of the Interaction and Cross-Regulation of Three Mycobacterium tuberculosis RelBE Modules.
• Characterization of the interaction between a SirR family transcriptional factor of Mycobacterium tuberculosis, encoded by Rv2788, and a pair of toxin-antitoxin proteins RelJ/K, encoded by Rv3357 and Rv3358.

The regulation of secondary metabolite (ε-poly lysine) biosynthesis in Streptomyces albus ZPM

School of Life Science

University of Science and Technology of China

2013 - 2014

• Identification of genetic variations associated with epsilon-poly-lysine biosynthesis in Streptomyces albulus ZPM by genome sequencing.

The distribution of type III-A CRISPR-Cas system in Staphylococcus aureus clinical isolates

School of Life Science

University of Science and Technology of China

2014 - 2015

• Identification and functional study of type III-A CRISPR-Cas systems in clinical isolates of Staphylococcus aureus.

The regulatory mechanism of drug susceptibility in mycobacteria

State Key Laboratory of Agricultural Microbiology

Huazhong Agricultural University

2012 - 2019

• InbR, a TetR family regulator, binds with isoniazid and influences multidrug resistance in Mycobacterium bovis BCG
• OxiR specifically responds to isoniazid and regulates isoniazid susceptibility in mycobacteria
• Cross-talk between the three furA orthologs in Mycobacterium smegmatis and the contribution to isoniazid resistance

Unearthing the mechanism of soil biofilms

College of Resources and Environment

Huazhong Agricultural University

2016 - 2019

• Bacillus subtilis biofilm development in the presence of soil clay minerals and iron oxides
• Co-culture of soil biofilm isolates enables the discovery of novel antibiotics
• Divergent Influence to a Pathogen Invader by Resident Bacteria with Different Social Interactions
• Soil biofilms: microbial interactions, challenges, and advanced techniques for ex-situ characterization
• Impact of metal oxide nanoparticles on in vitro DNA amplification

RNA-seq从入门到精通

华中农业大学暑期生物信息学培训班

武汉

2018-7-18

土壤生物化学课题组导师宣讲会

undergraduate students

Wuhan, CN

2018-6-8

土壤微生物组

undergraduate students

Wuhan, CN

2018-5-24

土壤中的多物种生物膜

graduated students

Wuhan, CN

2016-12-1

细菌的江湖——土壤微生物互作研究

华中农业大学资源与环境学院博士后交流会

武汉

2018-9-11

微生物之间的协作有利于细菌的存活和代谢

全国土壤生物生化与土壤健康学术研讨会

上海

2017

土壤生物膜的形成和群落演替

中国土壤学会第十三次全国会员代表大会

西安

2016

“Divergent influence to pathogen invader by environmental isolates with different social interactions”

The 2nd Global Soil Biodiversity Conference

Nanjing, CN

2017-10-19 - 2017-10-15

第一届生物信息学人才发展论坛

present

Zhuhai, CN

2019-7-28 - 2019-7-27

2019年“双一流”农科联盟暨学科建设研讨会

present

Wuhan, CN

2019-7-16

深圳市合成生物产业发展研讨会

present

Shenzhen, CN

2019-6-14

中国肠道大会

present

Beijing, CN

2019-5-6 - 2019-5-5

Sino-German Symposium on Microbiomics and Plant Health

present

Wuhan, CN

2018-9-24

未来组学术研讨会

present

Wuhan, CN

2018-8-8

农业微生物学国家重点实验室优秀研究生

10 each year

Wuhan, CN

2012 - 2011

优秀毕业研究生

n.a.

Wuhan, CN

2012

三好研究生

n.a.

Wuhan, CN

2011 - 2010

三好研究生

n.a.

Wuhan, CN

2009 - 2008

优秀毕业生

5 out of 45

Wuhan, CN

2008

三好学生

10 out of 45

Wuhan, CN

2007 - 2006

优秀团员

5 out of 45

Wuhan, CN

2006 - 2005

三好学生

10 out of 45

Wuhan, CN

2005 - 2004

Seven Facts and Five Initiatives for Gut Microbiome Research

Protein Cell, 2020, 11(6):391–400

N/A

2020

• Li, Danyi; Gao, Chun-Hui; Zhang, Faming; Yang, Ruifu; Lan, Canhui; Ma, Yonghui; Wang, Jun

Soil Biofilms: Microbial Interactions, Challenges, and Advanced Techniques for Ex-Situ Characterization

Soil Ecol. Lett., 2019, 1(3-4):85–93

N/A

2019

• Cai, Peng; Sun, Xiaojie; Wu, Yichao; Gao, Chun-Hui; Mortimer, Monika; Holden, Patricia A.; Redmile-Gordon, Marc; Huang, Qiaoyun

Cross-Talk between the Three furA Orthologs in Mycobacterium Smegmatis and the Contribution to Isoniazid Resistance

J Biochem, 2019, 166(3):237–243

N/A

• Gao, Chun-Hui; Wei, Wen-Ping; Tao, Hui-Ling; Cai, Li-Kai; Jia, Wan-Zhong; Hu, Lihua; Yang, Min

Divergent Influence to a Pathogen Invader by Resident Bacteria with Different Social Interactions

Microb Ecol, 2019, 77(1):76–86

N/A

• Gao, Chun-Hui; Zhang, Ming; Wu, Yichao; Huang, Qiaoyun; Cai, Peng

Impact of Metal Oxide Nanoparticles on in Vitro DNA Amplification

PeerJ, 2019, 7:e7228

N/A

• Gao, Chun-Hui; Mortimer, Monika; Zhang, Ming; Holden, Patricia A.; Cai, Peng; Wu, Shan; Xin, Yuexing; Wu, Yichao; Huang, Qiaoyun

Extraction of Extracellular Polymeric Substances (EPS) from Red Soils (Ultisols)

Soil Biology and Biochemistry, 2019, 135:283–285

N/A

• Wang, Shuang; Redmile-Gordon, Marc; Mortimer, Monika; Cai, Peng; Wu, Yichao; Peacock, Caroline L.; Gao, Chun-Hui; Huang, Qiaoyun

Soil Biofilm Formation Enhances Microbial Community Diversity and Metabolic Activity

Environment International, 2019, 132:105116

N/A

• Wu, Yichao; Cai, Peng; Jing, Xinxin; Niu, Xueke; Ji, Dandan; Ashry, Noha Mohamed; Gao, Chun-Hui; Huang, Qiaoyun

OxiR Specifically Responds to Isoniazid and Regulates Isoniazid Susceptibility in Mycobacteria

FEMS Microbiol Lett, 2019, 366(10):

N/A

• Yang, Min; Zhang, Li; Tao, Hui-Ling; Sun, Yuan-Chao; Lou, Zhong-Zi; Jia, Wan-Zhong; Hu, Li-Hua; Gao, Chun-Hui

Impact of Soil Clay Minerals on Growth, Biofilm Formation, and Virulence Gene Expression of Escherichia Coli O157:H7

Environmental Pollution, 2018, 243:953–960

N/A

2018

• Cai, Peng; Liu, Xing; Ji, Dandan; Yang, Shanshan; Walker, Sharon L.; Wu, Yichao; Gao, Chun-Hui; Huang, Qiaoyun

Co-Culture of Soil Biofilm Isolates Enables the Discovery of Novel Antibiotics

bioRxiv, 2018, 353755

N/A

• Gao, Chun-Hui; Cai, Peng; Li, Zhunjie; Wu, Yichao; Huang, Qiaoyun

Towards a Better Understanding of the Aggregation Mechanisms of Iron (Hydr)Oxide Nanoparticles Interacting with Extracellular Polymeric Substances: Role of pH and Electrolyte Solution

Science of The Total Environment, 2018, 645:372–379

N/A

• Lin, Di; Cai, Peng; Peacock, Caroline L.; Wu, Yichao; Gao, Chun-Hui; Peng, Wanxi; Huang, Qiaoyun; Liang, Wei

Metabolism, Survival, and Gene Expression of Pseudomonas Putida to Hematite Nanoparticles Mediated by Surface-Bound Humic Acid

Environmental Science: Nano, 2018

N/A

• Ouyang, Kai; L. Walker, Sharon; Yu, Xiao-Ying; Gao, Chun-Hui; Huang, Qiaoyun; Cai, Peng

Recent Advances in Microbial Electrochemical System for Soil Bioremediation

Chemosphere, 2018, 211:156–163

N/A

• Wu, Yichao; Jing, Xinxin; Gao, Chun-Hui; Huang, Qiaoyun; Cai, Peng

Survival of Escherichia Coli O157:H7 in Various Soil Particles: Importance of the Attached Bacterial Phenotype

Biol Fertil Soils, 2017, 53(2):209–219

N/A

2017

• Liu, Xing; Gao, Chun-Hui; Ji, Dandan; Walker, Sharon L.; Huang, Qiaoyun; Cai, Peng

Bacillus Subtilis Biofilm Development in the Presence of Soil Clay Minerals and Iron Oxides

npj Biofilms and Microbiomes, 2017, 3(1):4

N/A

• Ma, Wenting; Peng, Donghai; Walker, Sharon L.; Cao, Bin; Gao, Chun-Hui; Huang, Qiaoyun; Cai, Peng

Effects of Humic Acid on the Interactions between Zinc Oxide Nanoparticles and Bacterial Biofilms

Environmental Pollution, 2017

N/A

• Ouyang, Kai; Yu, Xiao-Ying; Zhu, Yunlin; Gao, Chun-Hui; Huang, Qiaoyun; Cai, Peng

Metal-Free Inactivation of E. Coli O157:H7 by Fullerene/C3N4 Hybrid under Visible Light Irradiation

Ecotoxicology and Environmental Safety, 2017, 136:40–45

N/A

• Ouyang, Kai; Dai, Ke; Chen, Hao; Huang, Qiaoyun; Gao, Chun-Hui; Cai, Peng

自然环境中的多物种生物膜:研究方法及社群相互作用

农业资源与环境学报, 2017, (01):6–14

N/A

• 孙晓洁; 高春辉; 黄巧云; 蔡鹏

大肠杆菌表面感应机制研究进展

浙江大学学报(农业与生命科学版), 2017, (06):685–690

N/A

• 王立亮; 高春辉; 吴一超; 黄巧云; 蔡鹏

Identification and Functional Study of Type III-A CRISPR-Cas Systems in Clinical Isolates of Staphylococcus Aureus

International Journal of Medical Microbiology, 2016, 306(8):686–696

N/A

2016

• Cao, Linyan; Gao, Chun-Hui; Zhu, Jiade; Zhao, Liping; Wu, Qingfa; Li, Min; Sun, Baolin

Identification of Genetic Variations Associated with Epsilon-Poly-Lysine Biosynthesis in Streptomyces Albulus ZPM by Genome Sequencing

Scientific Reports, 2015, 5:9201

N/A

2015

• Wang, Lin; Gao, Chun-Hui; Tang, Nan; Hu, Songnian; Wu, Qingfa

InbR, a TetR Family Regulator, Binds with Isoniazid and Influences Multidrug Resistance in Mycobacterium Bovis BCG

Scientific Reports, 2015, 5:13969

N/A

• Yang, Min; Gao, Chun-Hui; Hu, Jialing; Zhao, Lei; Huang, Qiaoyun; He, Zheng-Guo

Characterization of the Interaction between a SirR Family Transcriptional Factor of Mycobacterium~Tuberculosis, Encoded by Rv2788, and a Pair of Toxin-Antitoxin Proteins RelJ/K, Encoded by Rv3357 and Rv3358

FEBS J., 2014, 281(12):2726–2737

N/A

2014

• Yang, Min; Gao, Chun-Hui; Hu, Jialing; Dong, Chao; He, Zheng-Guo

A Novel marRAB Operon Contributes to the Rifampicin Resistance in Mycobacterium Smegmatis

PLoS ONE, 2014, 9(8):e106016

N/A

• Zhang, Haiwei; Gao, Long; Zhang, Jiaoling; Li, Weihui; Yang, Min; Zhang, Hua; Gao, Chun-Hui; He, Zheng-Guo

Characterization of a Novel ArsR-Like Regulator Encoded by Rv2034 in Mycobacterium Tuberculosis

PLoS ONE, 2012, 7(4):e36255

N/A

2012

• Gao, Chun-Hui; Yang, Min; He, Zheng-Guo

A TetR-like Regulator Broadly Affects the Expressions of Diverse Genes in Mycobacterium Smegmatis

Nucl. Acids Res., 2012, 40(3):1009–1020

N/A

• Yang, Min; Gao, Chun-Hui; Cui, Tao; An, Jingning; He, Zheng-Guo

An ArsR-like Transcriptional Factor Recognizes a Conserved Sequence Motif and Positively Regulates the Expression of phoP in Mycobacteria

Biochem. Biophys. Res. Commun, 2011, 411(4):726–731

N/A

2011

• Gao, Chun-Hui; Yang, Min; He, Zheng-Guo

Global Protein-Protein Interaction Network in the Human Pathogen Mycobacterium Tuberculosis H37Rv

J. Proteome Res., 2010, 9(12):6665–6677

N/A

2010

• Wang, Yi; Cui, Tao; Zhang, Cong; Yang, Min; Huang, Yuanxia; Li, Weihui; Zhang, Lei; Gao, Chun-Hui; He, Yang; Li, Yuqing; Huang, Feng; Zeng, Jumei; Huang, Cheng; Yang, Qiong; Tian, Yuxi; Zhao, Chunchao; Chen, Huanchun; Zhang, Hua; He, Zheng-Guo

Characterization of the Interaction and Cross-Regulation of Three Mycobacterium Tuberculosis RelBE Modules

PLoS ONE, 2010, 5(5):e10672

N/A

• Yang, Min; Gao, Chun-Hui; Wang, Yi; Zhang, Hua; He, Zheng-Guo

Dissecting Transcription Regulatory Pathways through a New Bacterial One-Hybrid Reporter System

Genome Res., 2009, 19(7):1301–1308

N/A

2009

• Guo, Manman; Feng, Hui; Zhang, Jun; Wang, Wenqin; Wang, Yi; Li, Yuqing; Gao, Chun-Hui; Chen, Huanchun; Feng, Ying; He, Zheng-Guo

Archaeal Eukaryote-like Orc1/Cdc6 Initiators Physically Interact with DNA Polymerase B1 and Regulate Its Functions

PNAS, 2009, 106(19):7792–7797

N/A

• Zhang, Lu; Zhang, Lei; Liu, Yi; Yang, Shifan; Gao, Chun-Hui; Gong, Hongchao; Feng, Ying; He, Zheng-Guo